T. J. O'Donnell
O'Donnell and Associates, Chicago, IL
16. Cyclooxygenase-2 and Celecoxib
Artist and computational biologist T. J. O'Donnell
creates molecular portraits of exceptional
clarity.
"Cyclooxygenase-2 and Celecoxib" depicts the interaction
between a drug and its target.
Aspirin acts by blocking the enzyme cyclooxygenase-2,
which is important in the transmission of pain signals. In
order to find new painkillers with fewer side effects,
researchers are studying the enzyme and searching for new
drug molecules to block its action. The colored cylinders
and strands represent the enzyme chain, and the white
dotted area at lower left is its deep active site. Blocking this
active site is a new inhibitor, celecoxib (shown in blue),
developed at Monsanto. Atomic coordinates were provided
by Ravi Kurumbail. The image is a barrier-strip
autostereogram produced by Ellen Sandor, Janine Fron, and
Stephan Meyer of Artn.
Larsen -
Carson -
Gaber -
Gillilan -
Johnson -
Maslak -
Moldoff -
Morris -
Nutt
O'Donnell -
Olson -
Palay -
Rothaus -
Suzuki -
Taylor -
Winslow -
Goodsell
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