The Scripps Research Institute
Department of Molecular Biology, MB-5
10666 North Torrey Pines Road
La Jolla, CA 92037
Ph.D., Biophysics, Stanford University, 1989
M.S., Chemical Engineering, Stanford University, 1984
B.S., Chemical Engineering, Princeton University, 1979
As an Assistant Member of The Scripps Research Institute I study protein structure, folding and dynamics. I am particularly interested in developing modeling tools for predicting protein-protein docking and protein-ligand interactions -- a key element in computer-aided drug design.
For this end, I developed the HARMONY program for generating spherical harmonic representations of protein surfaces. This method allows variable-resolution analysis of surfaces and surface properties, and the parametric representation is useful in developing efficient computational methods for predicting protein-protein interactions.
Spherical harmonics have interesting features for texture mapping , and can even represent surface motion computed by normal mode analysis . crambin movie (496K mpeg)
Computer graphics is a key element of this work, and I have developed modeling tools for the AVS visualization system and the AVStool command interface to display our results.
These images were produced at the Molecular Graphics Laboratory of The Scripps Research Institute under the direction of Dr. Art Olson.