Hello Sargis, I had installed PyRx version 0.8 in window 8, 64-bit operating system, x64-based processor and with python 2.7.8 ,microsoft visual C++ 2012.But when I used openbabel to convert the file from sdf to pbdqt and for energy minimization there have Runtime Error, Program:C:\Program Files (x86)\Pyrx\pythonw.exe.This application has requested the Runtime to terminate it in an unusual way and pythonw.exe has stopped working.The tittle of the error is Microsoft Visual C++ Runtime library.
Thank You
Regards
Aloysius